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KMID : 1039220190290010013
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Journal of Korean Society of Occupational and Environmental Hygiene
2019 Volume.29 No. 1 p.13 ~ p.20
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Recommendation of Occupational Exposure Limit through occupational hazard assessment of PHMG-Phosphate
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Lee Hye-Lim
Byeon Sang-Hoon
Lee Kwon-Seob
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Abstract
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Objective: This study was performed to propose a domestic occupational exposure limit(OEL) following a health hazard assessment, calculation of a non-carcinogenicity reference concentration worker(RfCworker) value, and examination of international agencies' exposure limits. It also recommends legal management within the Occupational Safety and Health Act for PHMG- Phosphate(CAS No. 89697-78-9), It is a humidifier disinfectant that generated many lung injuries.
Methods: We have investigated the recommendation or guidelines of foreign OEL for PHMG-Phosphate and the actual state of legal management in Korea. To examine the procedures and methods for recommendation OEL. Toxicological hazard and health hazard classifications were examined and a non-carcinogenicity RfCworker value was calculated for PHMG-Phosphate. An OEL and the necessity of legal management were recommended as well.
Results and Conclusions: The OEL for PHMG-Phosphate is recommended to be 0.01 mg/㎥. The recommended OEL is close to 10 times the RfCworker value of 0.000833 mg/㎥ calculated from the chemical dose-response hazard assessment, which is a 2017 study. The CMIT/MIT(3:1) mixture, which was a social issue as a humidifier disinfectant substance, was also exposed to the same ratio in March 2018, establish the OEL. It is recommended to establish OEL for PHMG-Phosphate to prevent worker health hazards and for chemical safety management.
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KEYWORD
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biocide, no observed adverse effect level(NOAEL), occupational exposure limits(OELs), PHMG, RfCworker
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